The National Football League is preparing to kick off the 2026 regular season in Seattle with a rematch of Super Bowl LX between the New England Patriots and the Seattle Seahawks.
The defending champion Seahawks open the season as 3.5-point home favorites against the visiting Patriots.
Following the opener, the action shifts internationally to Melbourne, Australia, where the Los Angeles Rams will host the San Francisco 49ers at the Melbourne Cricket Ground.
The Rams are currently listed as 3.5-point favorites for the Thursday matchup in Australia.
Describing the unpredictable nature of the opening slate, writer Tyler Sullivan noted that “this is one of the trickiest times to bet on the league calendar.”
A highly anticipated division rivalry will also take place at MetLife Stadium, where the Dallas Cowboys are scheduled to play the New York Giants.
The visiting Cowboys enter the matchup as 2.5-point favorites over the Giants, despite New York holding a home-field advantage under new head coach John Harbaugh.
In other notable matchups, the Los Angeles Chargers are the largest favorites of the opening week as they lay 10.5 points against the visiting Arizona Cardinals.
Meanwhile, the matchup between the Tampa Bay Buccaneers and the Cincinnati Bengals features the highest projected total on the board at 50.5 points.
Fans will also monitor the return of Kansas City Chiefs quarterback Patrick Mahomes, who is expected to start as a 3-point Monday night favorite against the Denver Broncos after recovering from a major knee injury.