Delaware State saw its hopes for a MEAC football title vanish following a 30-24 loss to Howard at Greene Stadium on Nov. 13.
The defeat leaves the Hornets with a 6-5 overall record and a 2-2 mark in conference play, according to Yahoo Sports.
Howard, which improved to 5-6 overall and 2-2 in the MEAC, utilized a strong second half to secure the win.
The Bison scored twice in the third quarter to take a 28-21 lead, an advantage they maintained for the remainder of the contest.
Delaware State initially jumped to a 14-0 lead in the first quarter thanks to two touchdown runs from Jayden Jenkins.
Sean Weston later added a 3-yard touchdown run to give the Hornets a 21-14 advantage heading into halftime.
The momentum shifted after the break as Howard dominated the total yardage battle, finishing with 451 yards compared to 229 for Delaware State.
Billy Roberson II proved instrumental for the Bison, rushing for 160 yards on 28 carries and scoring three touchdowns.
For the Hornets, Paul Kamden recorded 90 rushing yards on 10 carries.
Quarterback Ui Ale struggled to move the offense, completing 9 of 19 passes for 46 yards while suffering five sacks and one interception.
Matteo Bracalenti provided a glimmer of hope for Delaware State with a 42-yard field goal with 6:45 remaining, narrowing the deficit to 28-24.
However, the Hornets were forced to punt from deep in their own territory on their subsequent possession.
The team failed to threaten again and eventually surrendered a late safety to finalize the score.
The outcome was described as a crucial MEAC football defeat by the Delaware News Journal.
Delaware State is now scheduled to visit first-place South Carolina State on Nov. 21 for the final game of the season.
The Hornets will look to conclude their campaign on a positive note following the disappointment in Washington, D.C.